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ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins
Honghui Zhou, Frank-Peter Theil , "ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins: Applications in Drug Discovery and Development"
2016 | ISBN-10: 1118898648 | 480 pages | PDF | 20 MB

With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs.
Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs
Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective
Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines
Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan
Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain



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ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins
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Tags: Translational, Pharmacokinetic, Pharmacodynamic, Therapeutic, Proteins

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