"Herpesviridae" ed. by Jozsef Ongradi
ITexLi | 2016 | ISBN: 9535126113 9535126105 | 261 pages | PDF | 27 MB
This book is intended to give an overview on selected clinical hot topics: herpes simplex virus encephalitis, persistent infection in the gingiva, thymidine kinase gene expression causing male infertility, and pharmaceutical reactivation of Epstein-Barr virus for oncolysis. Immune evasion mechanisms and new ways to formulate vaccines are exhaustively reviewed.
Herpesviruses are unique among viruses as they encode for a complex self-regulatory system, aggressively invade and persist in the host, evade immune defense, alter all regulatory mechanisms of the macroorganism and modify the replication of heterologous viruses. Environmental factors influence these unconventional relationships. Consequently, a single herpesvirus species can be attributed to a wide range of diseases as etiological agents or cofactors.
Finally, a surprise: bovine herpesviruses could serve as models to study the pathomechanism of herpesviruses.
1 Introductory Chapter: Unconventional Philosophy of Herpesvirus Infections
2 Herpes Simplex Virus Type 1 at the Central Nervous System
3 Herpesviruses in Periapical Pathoses: An Updated Systematic Review
4 Ectopic Expression of Human Herpesvirus 1 Thymidine Kinase Induces Male Infertility
5 Immune Evasion by Herpes Simplex Viruses
6 Review: Biological and Pharmacological Basis of Cytolytic Viral Activation in EBV-Associated Nasopharyngeal Carcinoma
7 Herpes Simplex Virus 1 and 2 Vaccine Design: What can we Learn from the Past?
8 Herpesvirus in Bovines: Importance of Bovine Herpesvirus Type 1
9 Latency of Bovine Herpesvirus 1 (BoHV-1) in Sensory Neurons
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