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Innate Tolerance in the CNS: Translational Neuroprotection by Pre- and Post-Conditioning
Jeffrey M. Gidday, Miguel A. Perez-Pinzon, John H. Zhang - Innate Tolerance in the CNS: Translational Neuroprotection by Pre- and Post-Conditioning
Published: 2012-09-21 | ISBN: 144199694X | PDF | 699 pages | 7 MB

Cerebral ischemia from cardiac arrest, stroke, and subarachnoid and intracerebral hemorrhage, together with trauma, epilepsy, and other CNS pathologies, continue to impose immense burdens of morbidity and mortality the world over. Despite many decades of research aimed at understanding the genetic and molecular basis of these pathologies, therapeutics developed on the basis of blocking ‘known' injury mechanisms can actually claim few clinical successes. The field of CNS "preconditioning" was born from the preclinical finding more than 20 years ago that intentional activation of innate, cytoprotective factors could provide robust protection, or "tolerance" against cerebral ischemic injury.
Herein, up-to-date summaries on all aspects of preconditioning for CNS disease, including the emerging topics of postconditioning and remote pre- and post-conditioning, are provided by the leading scientists in the field. The translational potential of both preclinical and clinical advances is underscored throughout, with the hope of accelerating the bench-to-bedside success of endogenous cytoprotection as a therapeutic strategy.
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Tags: Innate, Tolerance, Translational, Neuroprotection

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